Leydig-Zell-Tumor des Hodens

Fibrous

dysplasia for radiologists: beyond ground glass bone matrix. Testicular abnormalities in McCune-Albright syndrome in three different patients. a, b Ultrasound (US) of the testicles shows extensive echogenic material secondary to Leydig cell hyperplasia. c, d The heterogeneous appearance of the testicle with more focal, well-circumscribed areas of abnormal echogenicity. These imaging findings correlate with Leydig cell hyperplasia on pathology. e, f The right testicle appears atrophic and demonstrates inhomogeneous echotexure and multiple punctate calcifications

insightsimaging.springeropen.com • Open Access

Leydig cell

tumor of the testis: an incidental finding at 18F-FDG PET/CT imaging. a–c FDG PET/CT images demonstrate incidental finding of focal increase right testicular uptake seen with more metabolic activity in relation to the remaining testicular tissues (SUVmax 2.9). No specific findings in other areas or definitive FDG avid lymphadenopathy

ejrnm.springeropen.com • CC-by-4.0

Leydig cell

tumor of the testis: an incidental finding at 18F-FDG PET/CT imaging. a Testicular US shows a well-circumscribed, encapsulated mass at the upper pole of the right testicle, measures 1.1 x 1.1 cm. b Color Doppler image shows significant internal vascularity of mass

ejrnm.springeropen.com • CC-by-4.0

Radiopaedia • CC-by-nc-sa 3.0 • de

A Leydig cell tumor of the testis is an uncommon testicular neoplasm. Its imaging appearance on ultrasound and MRI is nonspecific, but clinically it is associated with serum hormonal imbalance.

Epidemiology

1-3% of all testicular tumors, but the most common sex-cord stromal tumor. Tend to be bimodal, with one peak occurring in pediatric patients (5-10 years) and one in adults (20-30 years). Malignancy occurs in ~10% of tumors.

Pathology

Leydig cell tumors arise from the interstitial cells of Leydig adjacent to the seminiferous tubules.

Clinical presentation

Leydig cell tumors of the testis may present with serum hormonal imbalance (~30%). Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynecomastia.