Rai staging of chronic lymphoid leukaemia
The Rai staging system is one of the two staging systems currently adopted in assessment of chronic lymphocytic leukemia (CLL).
It comprises of stages 0 to IV and classifies chronic lymphocytic leukemia into low, intermediate and high-risk categories, which correspond with stages 0, I & II, and III & IV, respectively:
- Rai stage 0
- low risk
- lymphocytosis: a high lymphocyte count defined as more than 15,000 lymphocytes per cubic millimeter (> 15,000/mm)
- Rai stage I
- intermediate risk
- lymphocytosis and lymphadenopathy
- Rai stage II
- patients are also intermediate risk
- lymphocytosis plus an enlarged liver (hepatomegaly) or enlarged spleen (splenomegaly), with or without lymphadenopathy
- Rai stage III
- patients are high-risk
- lymphocytosis plus anemia with or without lymphadenopathy, hepatomegaly, or splenomegaly
- Rai stage IV
- high-risk
- lymphocytosis + thrombocytopenia (< 100-103 /dL)
See also
