Intertwin membrane folding

Intertwin membrane folding is an observation where the intertwin membrane in a twin pregnancy appears as being folded. It is sometimes used as a predictor for the development of twin to twin transfusion syndrome. It occurs as a result of amniotic fluid discordance.

Some reports suggest that folding of the inter-twin membrane occurs in about one-quarter of monochorionic twins wherein ~43-50% half of these there can be a subsequent development of twin-to-twin transfusion syndrome .