Fundic gland polyp

Fundic gland polyps (FGP) are the most common type of gastric polyp.

Epidemiology

FGPs occur most commonly in middle-aged females. They have been reported to be identified in ~1% of gastroscopies .

Clinical presentation

FGPs are usually an asymptomatic, incidental finding .

Pathology

FGPs account for ~60% (range 47-77%) of gastric polyps . They may arise sporadically or be part of the syndrome (e.g. familial adenomatous polyposis), although there are different genetic mutations between sporadic and FAP-associated cases .

The pathogenesis remains unclear, and there may be an association with antacid medications (e.g. proton pump inhibitors) and reduced rates of Helicobacter pylori infections.

Macroscopic appearance

FGPs arise in the gastric body and fundus, and are sessile, measuring <10 mm (normally 1-5 mm) in size. They may be multiple or single .

Treatment and prognosis

FGPs are benign with no malignant potential .