Anti-GQ1b IgG antibody syndrome
Anti-GQ1b IgG antibody syndrome refers to a number of conditions which share autoantibodies to the ganglioside complex GQ1b, and have overlapping clinical spectrums.
The conditions believed to represent various clinical manifestations of a common immunological disorder include :
- acute ophthalmoparesis without ataxia
- Bickerstaff brainstem encephalitis
- Guillain-Barré syndrome
- Miller Fisher syndrome
The exact relationship between these entities, and what determines the clinical phenotype remains unclear, possibly relating to the exact specificity of the anti-GQ1b antibodies and how these are expressed throughout the nervous system .
