pick disease
Pick disease is a neurodegenerative disease, and one of the tauopathies characterized by the accumulation of Pick bodies.
Terminology
Pick disease is sometimes used synonymously with frontotemporal lobar degeneration, although this is probably unwise, as not all cases which fit clinically into a frontotemporal dementia have the underlying pathological changes seen in Pick disease.
Epidemiology
Pick disease typically manifests between the ages of 40 and 60 years, with a male predilection .
Clinical presentation
Clinical presentation depends on the particular pattern of cortical involvement, and is discussed in the frontotemporal lobar degeneration (FTLD) article.
Pathology
The characteristic features of Pick disease include :
- Pick bodies
- swollen chromatolytic neurons
- loss of large pyramidal neurons
- astrocytic gliosis
Radiographic features
The primary radiographic abnormality is that of cortical atrophy of the frontal and temporal lobes. These changes can be markedly asymmetric and affect one region much more than another. They are discussed further in the frontotemporal lobar degeneration (FTLD) article.
Caudate head volumes are also often reduced .
Differential diagnosis
Imaging differential diagnosis
On imaging, Pick disease may mimic other causes of frontal and temporal atrophy, especially:
- other varieties of frontotemporal lobar degeneration (FTLD)
- Alzheimer disease: parietal lobe involvement is more pronounced
- corticobasal degeneration: parietal lobe involvement is usually dominant
Clinical differential diagnosis
Clinically Pick disease may overlap with other neurodegenerative diseases with prominent frontal involvement, including :
- other varieties of frontotemporal lobar degeneration (FTLD)
- frontal variants of Alzheimer disease
Siehe auch:
- Kortikobasale Degeneration
- Typen der Demenz
- frontotemporal lobar degeneration (FTLD)
- Atypische Parkinson-Syndrome
- frontal variant frontotemporal dementia (fvFTD)
- Morbus Alzheimer
und weiter:
Assoziationen und Differentialdiagnosen zu Frontotemporale Demenz:
