adie syndrome

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Adie syndrome, also known as Holmes-Adie syndrome, is a rare neurological disorder.

Epidemiology

Adie syndrome is a rare condition which is most commonly seen in young females in their fourth decade of life .

Clinical presentation

Patients most commonly present with a classic triad of:

  • diaphoresis
  • absent deep tendon reflexes, e.g. ankle jerk
  • an Adie pupil: tonically dilated and responds poorly or not at all to light

    • Unilateral pupillary symptoms are more common than bilateral .

    Pathology

    It is thought to result form damage to the ciliary ganglion and the dorsal root ganglion by viral or bacterial infections, however there are idiopathic etiologies .

    History and etymology

    It was named after the British-Australian neurologist William John Adie (1886 - 1935) .