Hypervitaminosis B6
Vitamin B6 excess (hypervitaminosis B6) is caused by excessive consumption of supplemental pyridoxine, which is used as a therapeutic agent for several conditions.
Epidemiology
This hypervitaminosis is almost exclusively seen in those taking pyridoxine as prescription medication, it remains in use for a range of conditions, including isoniazid-related neuropathy, carpal tunnel impingement syndrome, pregnancy related nausea and vomiting, in restoration of cognitive function, mushroom poisoning, and some rare genetic disorders .
Clinical presentation
The classic presentation of pyridoxine chronic high dosing is with a sensory neuropathy, which in several published case reports has been so severe as to impair ambulation. The other sequela reported is a dermatosis. Other putative toxicity remains contentious.
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