End-diastolic volume

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The end-diastolic volume (EDV) is referred to as the volume of blood in the left or right ventricle at the end of the diastolic filling phase immediately before the beginning of systole.

Terminology

The end-diastolic volume index (EDVI) is referred to as the end-diastolic volume (EDV) corrected for the body surface area (BSA).

Usage

The end-diastolic volume is an essential parameter used for the assessment of cardiac function, namely the calculation of the respective stroke volumes and ejection fraction and the estimation of left or right ventricular preload.

It has a central role in the diagnosis of many cardiac conditions.

Measurement

MRI

Widely-used postprocessing software solutions for cardiac MRI employ a combination of semi-automated feature recognition and manual contour correction based on Simpson’s method (“summation of disks”) .

The end-diastolic volume (EDV) is determined by the sum of the computed left/right ventricular cross-sectional areas determined by the endocardial contours at the end of the diastolic filling phase (chosen as the images with the largest blood volume) accounting for slice thickness and gap .

End-diastolic volume index (EDVI) is calculated as: EDVI = EDV/BSA [mL/m]

Papillary muscles are often included in the blood volumes. The ventricular outflow tract should also be included .

Interpretation

Normal values differ for the left and right ventricle depending on gender and age and with the imaging modality used :

MRI

Normal values are derived for 1.5 tesla from the publication by Kawel-Boehm :

Left ventricle

Women (20-80 years):

  • EDV [mL]:            86-178 mL
  • EDVI [mL/m]:    56-96 mL/m

Men (20-80 years):

  • EDV [mL]:            106-214 mL
  • EDVI [mL/m]:    57-105 mL/m    

Values above the normal indicate left ventricular dilatation, which can be further categorized in mildly moderately or severely dilated.

Right ventricle

Women (20-68 years):

  • EDV [mL]:            77-201 mL
  • EDVI [mL/m]:    48-112 mL/m

Men (20-68 years):

  • EDV [mL]:            118-250 mL
  • EDVI [mL/m]:    61-121 mL/m    

Values above the normal indicate right ventricular dilatation, which can be further categorized in mildly moderately or severely dilated.