Adenocarcinoma of the lacrimal glands

Adenocarcinoma
of lacrimal gland. T1W coronal MRI shows an intermediate intensity right lacrimal fossa mass.
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Adenocarcinoma
of the lacrimal glands • Adenocarcinoma of the lacrimal glands - Ganzer Fall bei Radiopaedia
Donato A, Adenocarcinoma of the lacrimal glands. Case study, Radiopaedia.org (Accessed on 13 May 2024) https://doi.org/10.53347/rID-72360 • CC by-nc-sa 3.0 (modified)
Adenocarcinoma
of lacrimal gland. T2W coronal MRI shows a hyperintense right lacrimal fossa mass.
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Adenocarcinoma
of lacrimal gland. Post-contrast T1W coronal MRI shows a right lacrimal fossa mass with heterogeneous post-gadolinium enhancement.
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Adenocarcinoma
of lacrimal gland. Images show a rounded extraconal mass centred on the right lacrimal gland at the superolateral aspect of the right orbit, with strong peripheral and mild central heterogeneous enhancement.
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Adenocarcinoma
of lacrimal gland. Images show a rounded extraconal mass centered on the right lacrimal gland along the superolateral aspect of the right orbit, with strong peripheral and mild central heterogeneous enhancement.
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Adenocarcinoma
of lacrimal gland. B1000 diffusion weighted image (DWI) showing partially hyperintense right lacrimal fossa lesion.
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Adenocarcinoma
of lacrimal gland. Apparent diffusion coefficient (ADC) map showing areas of reduced signal within the right lacrimal fossa lesion, consistent with restricted diffusion.
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Adenocarcinoma of the lacrimal glands is rare, with few cases reported in the literature since it was first described in 1996 . Primary adenocarcinoma of the lacrimal gland is extremely rare; only 9 cases have been reported in the literature . It can be classified into high- and low-grade malignancies. This neoplasm is histologically and immunohistochemically similar to salivary ductal carcinoma .

Clinical presentation

They usually present as unilateral gland enlargement with displacement of the eye.

Pathology

Histologic examination shows a well-circumscribed but unencapsulated neoplasm. The cells are highlighted by the calponin immunostain, consistent with myoepithelial differentiation. These cells have round to oval nuclei with a uniform vesicular chromatin pattern and small nucleoli. Most of these cells exhibit cytoplasmic and membranous staining for C-kit (CD117). p53 expression is seen in a minority of the nuclei. A significant number of luminal structures contain mucicarmine-positive material. The tumor cells are uniformly negative for GFAP.

Radiographic features

A rounded extraconal mass centered around the lacrimal gland in the superolateral aspect of the orbit.

CT

Axial and coronal CT shows peripheral and mild central heterogeneous enhancement.

MRI

Signal characteristics include:

  • T1: intermediate intensity lacrimal fossa mass
  • T2: usually hyperintense
  • T1 C+: heterogeneous enhancement
  • DWI and ADC: diffusion restriction of the peripherally enhancing component

Treatment and prognosis

The tumor is usually treated with complete excision, lymph node dissection, and adjuvant radiotherapy. Because there are few reports of this entity, its clinical behavior, prognosis and definitive treatment are still unknown .

Differential diagnosis

Possible differential considerations include:

See also

Siehe auch:
Assoziationen und Differentialdiagnosen zu Adenokarzinom der Glandula lacrimalis:
inflammatorischer
Pseudotumor der Orbita
jmedicalcasereports.biomedcentral.com • CC-by-2.0
Tumoren der
Tränendrüse
www.eurorad.org • CC by-nc-sa-4.0
Lymphom der
Tränendrüse
Wikipedia • CC BY-SA 4.0
Sarkoidose
der Glandula ladrimalis
insightsimaging.springeropen.com • CC-by-4.0