Ariboflavinosis

Ariboflavinosis is the term given to riboflavin (vitamin B2) deficiency.

Epidemiology

Ariboflavinosis has been seen in both developed and developing countries, and across the socioeconomic spectrum. It is usually present in the context of other hypovitaminoses.

It has been found to more common in those with chronic disease, including malignancies, diabetes mellitus and heart disease, however this may not be a causal relationship.

Prevalence is not known.

Clinical presentation

A deficiency of riboflavin tends to present with an inflammation of the mucous membranes of the oral cavity and pharynx. Patients may experience sore throats, cheilitis, angular stomatitis, and glossitis ("magenta tongue"). Seborrheic dermatitis and a normocytic anemia may be seen.

Pathology

With marked ariboflavinosis, the metabolism of vitamin B3 (niacin) and B6 (pyridoxine) may be significantly impaired.