diffuse uterine leiomyomatosis

Diffuse uterine leiomyomatosis is a benign and extremely rare condition in which the uterus is symmetrically enlarged as a result of the almost complete replacement of the myometrium by innumerable poorly defined, confluent leiomyomatous nodules.

Clinical presentation

Initial symptoms of the diffuse uterine leiomyomatosis usually are abdominal pain and abnormal uterine bleeding. Similar to uterine leiomyomas, patients with leiomyomatosis can present with menorrhagia, dysmenorrhea, abdominal pain, infertility, and pelvic pressure.


The exact etiology of these neoplasms is incompletely understood.

Radiographic features

  • is the method of choice
  • the uterus appears diffusely enlarged showing multiple innumerable ill-defined leiomyomas without discrete margins

Differential diagnosis

See also

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