Drug and toxin induced pulmonary hypertension

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Drug and toxin induced pulmonary hypertension is one of the causes of pulmonary arterial hypertension. It falls under group 1.3 under the Dana point classification system of pulmonary hypertension.

Pathology

A wide range of difference drugs have been associated with developing pulmonary hypertension:

  • appetite suppressant drugs: have been withdrawn from the market
    • aminorex
    • fenfluramine derivatives
    • benfluorex
    • phenylpropanolamine
  • amphetamines
  • phentermine
  • mazindol 
  • dasatinib: a dual Src/Abl kinase inhibitor, used in the treatment of chronic myelogenous leukemia 
  • interferon: possible
  • possible agents
    • phenylpropanolamine
    • L-tryptophan
    • certain selective serotonin reuptake inhibitors: pergolide

Radiographic features

Refer to the main article on pulmonary hypertension.