Fibrotic non-specific interstitial pneumonitis

Fibrotic
non-specific interstitial pneumonitis • Non-specific interstitial pneumonia - Ganzer Fall bei Radiopaedia
Kuok Y, Non-specific interstitial pneumonia. Case study, Radiopaedia.org (Accessed on 28 Feb 2023) https://doi.org/10.53347/rID-17341 • CC by-nc-sa 3.0 (modified)
Fibrotic
non-specific interstitial pneumonitis • Non-specific interstitial pneumonia - Ganzer Fall bei Radiopaedia
Guarneri R, Non-specific interstitial pneumonia. Case study, Radiopaedia.org (Accessed on 28 Feb 2023) https://doi.org/10.53347/rID-31651 • CC by-nc-sa 3.0 (modified)
Radiopaedia • CC-by-nc-sa 3.0 • de

Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form . This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis .

Treatment and prognosis

Corticosteroid can be given but it carries a worse prognosis than the cellular type.

Differential diagnosis

The key imaging differential is a UIP pattern

  • according to one study 62% of patients with UIP showed subpleural predominance whereas 55% of patients with fibrotic NSIP exhibited random distribution
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