Gadobenate dimeglumine

Gadobenate dimeglumine (also known as MultiHance) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

• linear, ionic molecule 
• 95-96% renal excretion, 4-5% hepatic excretion
• T1 relaxivity @ 1.5 T: 6.0-6.6
• concentration: 0.5 mmol/mL
• recommended dosage: 0.1 mmol/kg

Indications

As an extracellular contrast agent, gadobenate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.

Because it has 4-5% hepatobiliary uptake, it can be used as a hepatobiliary phase agent in some circumstances but requires a 1-hour delay for imaging acquisition.

Because of the higher relaxivity than most other extracellular contrast agents, it is preferred in vascular imaging. Gadofosveset trisodium (Ablavar) has approximately 3-4 times the relaxivity of gadobenate dimeglumine but is considered a blood pool agent and its commercial availability is limited.

The high relaxivity of gadobenate dimeglumine also makes it a preferred agent for imaging:

• combined abdomen and pelvis imaging
• MR enterography
• MR urography
• MR perianal fistula

Gadobenate dimeglumine has been reported as having a low rate of acute adverse reactions (0.17% rate of total adverse effects with <0.01% serious adverse effects) .

Siehe auch:

• Primovist

und weiter:

• gallengängiges Kontrastmittel