Histoplasmoma is the name for a specific kind of nodule secondary to granulomatous reaction to histoplasmosis infection often described as having a pathognomic target lesion appearance.

Histoplasmomas can appear in the lungs or central nervous system. Although classically conceived as a solitary lesion, there are reports of multiple histoplasmomas in a single patient . Histoplasmomas vary in size and may grow over time, and can even exceed the technical definition of a pulmonary nodule's size (i.e. >3 cm) .