Holman-Miller sign (maxillary sinus)
The Holman-Miller sign (also called the antral sign) is seen in juvenile nasopharyngeal angiofibroma; it refers to the anterior bowing of the posterior wall of the maxillary antrum as seen on a lateral skull radiograph or cross-sectional imaging .
This is a non-specific sign that can be produced by any slowly-growing mass, whereas erosion of the pterygoid lamina may be pathognomonic for juvenile nasopharyngeal angiofibroma .
History and etymology
Colin B Holman and W Eugene Miller, American radiologists, described their eponymous sign on plain radiographs in a paper in 1965 .