Hot cross bun sign (pons)
Imaging
biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts. MRI of a patient with a clinical diagnosis of Multiple System Atrophy-C. a Axial proton density sequence at the level of the pons demonstrates cruciform pontine T2 hyperintensity consistent with the ‘hot cross bun’ sign secondary to selective vulnerability of the pontocerebellar tract in Multiple System Atrophy-C. Disproportionate atrophy of the pons and partially visualized cerebellar hemispheres is also evident. b Axial FLAIR sequence with cruciform T2 hyperintensity within the pons and middle cerebellar peduncles (i.e., ‘Middle Cerebellar Peduncle sign’) with marked atrophy. Cerebellar hemispheric and vermian atrophy is also seen with ex vacuo dilatation of the fourth ventricle. c Sagittal T1 sequence showing marked atrophy of the brainstem and cerebellar vermis
The hot cross bun sign refers to the MRI appearance of the pons when T2 hyperintensity forms a cross on axial images, representing selective degeneration of pontocerebellar tracts. It has been described in a variety of neurodegenerative diseases :
- multiple system atrophy (MSA)
- spinocerebellar ataxia (various types)
- cerebral vasculitis (causing Wallerian degeneration of pontocerebellar tracts)
- variant Creutzfeldt-Jakob disease (vCJD)
- JC virus granule cell neuronopathy
Siehe auch:
- Multisystematrophie
- hot-cross bun sign of multiple system atrophy
- variant Creutzfeldt-Jakob disease (vCJD)
- neurodegenerative Erkrankung
und weiter:
Assoziationen und Differentialdiagnosen zu Sternsemmel-Zeichen:
hot-cross bun
sign of multiple system atrophy