hyaline degeneration of a leiomyoma

Hyaline degeneration is the most common form of degeneration that can occur in a uterine leiomyoma.


It is thought to occur in up to 60% of uterine leiomyomas .


As with many other types of degeneration, it happens when fibroids outgrow their blood supply . Hyaline degeneration involves the presence of homogeneous eosinophilic bands or plaques in the extracellular space, which represent the accumulation of proteinaceous tissue .

Radiographic features


Typical signal characteristics of a leiomyoma with hyaline or calcific degeneration are difficult to distinguish from non-degenerated fibroids on pelvic MRI. Areas of calcification can appear as signal voids on MRI .

Therefore typical characteristics include :

  • T1: isointense
  • T2: hypointense
  • T1 C+ (Gd): low enhancement in comparison to regular leiomyoma
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