intrathekale Methotrexatapplikation

Apparent

diffusion coefficient restriction in the white matter: going beyond acute brain territorial ischemia. This 14-year-old girl affected by acute lymphocytic leukaemia and treated with intrathecal MTX acutely developed hemiparesis and aphasia. Axial diffusion-weighted (a), FLAIR (c) and T2-weighted images (d) showed bilateral T2 hyperintense lesions within the deep fronto-parietal white matter (arrows). ADC maps (b) presented reduced diffusivity. The neurological deficits and the DWI/ADC abnormalities resolved completely within 1 week, while slight T2 hyperintensities persisted on follow-up examinations