invasives duktales Karzinom

Multimodality
approach to the nipple-areolar complex: a pictorial review and diagnostic algorithm. Invasive ductal carcinoma (II). a Photograph of a 54-year-old woman with left nipple retraction. b Mammogram shows skin thickening and increased retroareolar density; c on ultrasound, the lesion is hypoechogenic and ill-defined. d MRI shows a large lesion in the left breast involving the nipple-areolar complex. e Hematoxylin-eosin stain (× 4) shows lymphatic invasion of the dermis of the nipple by infiltrating ductal carcinoma (arrows)
insightsimaging.springeropen.com • CC-by-4.0
Multimodality
approach to the nipple-areolar complex: a pictorial review and diagnostic algorithm. Invasive ductal carcinoma (I). An 88-year-old woman with a palpable nodule in the lower inner quadrant of her left breast. a Synthesized 2D mammogram shows a spiculated nodule (circle), classified as infiltrating lobular carcinoma at histology. Note the thickening of the skin and of the nipple-areolar complex (arrows). b MRI shows pathologic asymmetric enhancement of the left nipple-areolar complex. c Hematoxylin-eosin stain of punch-biopsy specimen (× 10) shows extensive dermal infiltration by infiltrating ductal carcinoma. d Immunohistochemistry (× 4) shows diffuse nuclear expression of estrogen receptors. These are two synchronous tumors
insightsimaging.springeropen.com • CC-by-4.0
Invasive
ductal carcinoma • Metastasizing infiltrating ductal carcinoma of the breast - Ganzer Fall bei Radiopaedia
ElBeialy, M. Metastasizing infiltrating ductal carcinoma of the breast. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-23487 • CC by-nc-sa 3.0 (modified)
Invasive
ductal carcinoma • Invasive ductal breast carcinoma - no special type - Ganzer Fall bei Radiopaedia
Knipe, H. Invasive ductal breast carcinoma - no special type. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-38200 • CC by-nc-sa 3.0 (modified)
Invasive
ductal carcinoma • Double recurrence of breast tumor at mastectomy site - Ganzer Fall bei Radiopaedia
Díaz, M. Double recurrence of breast tumor at mastectomy site. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-30087 • CC by-nc-sa 3.0 (modified)
Invasive
ductal carcinoma • Metastasizing infiltrating ductal carcinoma of the breast - Ganzer Fall bei Radiopaedia
ElBeialy, M. Metastasizing infiltrating ductal carcinoma of the breast. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-23487 • CC by-nc-sa 3.0 (modified)
Dual-energy
contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study. Multifocal invasive ductal carcinoma in a 53-year-old woman with dense breasts. The ultrasound image clearly demonstrates a 26-mm hypoechoic mass with irregular margins highly suggestive of malignancy.
breast-cancer-research.biomedcentral.com •
Radiopaedia • CC-by-nc-sa 3.0 • de

Invasive ductal carcinoma not otherwise specified, also known as invasive carcinoma of no special type, is the most common type of breast cancer. It is an infiltrating, malignant and abnormal proliferation of neoplastic cells in the breast tissues.

Terminology

The latest (4) edition of the World Health Organization classification of tumors of the breast changed the preferred terminology from invasive ductal carcinoma, not otherwise specified (NOS) to invasive (breast) carcinoma of no special type (NST) . The rationale is that the use of 'ductal' relies on unproven histogenetic assumptions for this heterogeneous group of cancers. Invasive ductal carcinoma or ductal NOS remains acceptable and commonly used terms.

Epidemiology 

Peak age of presentation is about 50 to 60 years.

Clinical presentation 

Large palpable, immobile mass.

Radiographic features

Mammogram
Ultrasound
  • ill-defined lesion
  • hypoechoic mass
  • hyperechoic angular margins
  • posterior acoustic shadowing
  • ductal extension may be seen which is extension of the lesion into surrounding parenchyma
  • branched or spiculated pattern
  • microcalcifications
MRI
  • T1
    • isointense to parenchyma
    • hypointense to fat
  • T1 C+ (Gd)
    • ring enhancement with centripetal progression
    • dilated veins draining the tumor
  • T2
    • iso to hypointense to parenchyma
    • hyperintense edematous zone
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