lewy bodies

Lewy bodies are intracellular cytoplasmic inclusions which result from abnormal alpha-synuclein metabolism (thus diseases with Lewy bodies are synucleinopathies). They also contain other proteins (ubiquitin and alpha B crystallin), fatty acids, sphingomyelin, and polysaccharides .

Lewy bodies are found in:

  • Parkinson disease
  • Lewy body dementia
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