Morbus Wegener Hypophysenbeteiligung

Severe

ophthalmic manifestation in pituitary-involved granulomatosis with polyangiitis: a case report and literature review. Magnetic resonance imaging (MRI) scans from the first episode: a Enhanced sagittal T1 sequence: enlarged pituitary fossa with a lesion convex to the suprasellar area. The pituitary stalk was compressed. The size of the lesion was 43*15*17 mm, with a slightly long T1 and long T2 signal mixed with a short T1 signal and a long T2 signal with inhomogeneous enhancement. No obvious bone destruction was detected. b Enhanced coronal T1 sequence: optic chiasm compression with the bilateral cavernous sinus surrounded by the lesion. c Enhanced sagittal T1 sequence: the volume of the lesion was reduced significantly after IV glucocorticoid treatment. d Enhanced coronal T1 sequence: the morphology of the optic chiasm and cavernous sinus returned to normal after IV glucocorticoid administration

Severe

ophthalmic manifestation in pituitary-involved granulomatosis with polyangiitis: a case report and literature review. Magnetic resonance imaging (MRI) scans at recurrence and after biopsy. a Enhanced sagittal T1 sequence: scans after the recurrence of headache in Sept. 2014 showed an enlarged sella with a slightly sunken bottom. The pituitary was enlarged with a height of 1.15 cm and showed a heterogeneous signal, with a patchy, short T1 signal and an abnormal, long T2 signal. The pituitary stalk was shortened and thickened. b Enhanced coronal T1 sequence: a new lesion was detected after recurrence. There was nodular enhancement with abnormal T1 and T2 signals on the right side of the suprasellar region; the lesion was invading the pituitary stalk, infundibulum, right optic nerve, posterior right basal gyrus rectus of the frontal lobe, anterior perforated substance and extending to the internal carotid artery. c and d Enhanced T2 sequence: cerebral parenchymal edema was detected around the lesion. e Enhanced sagittal T1 sequence: changes were observed in the pituitary after the biopsy and i.v. administration of glucocorticoids. f Enhanced coronal T1 sequence: after the biopsy and i.v. administration of glucocorticoids, the parenchymal edema was significantly reduced

Severe

localised granulomatosis with polyangiitis (Wegener’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. MR images of the brainstem, skull base and pituitary gland. (a) Coronal contrast-enhanced fat-saturated T1-weighted image of the central skull base demonstrates pathological enhancement of the cavernous sinus, pituitary gland and pituitary stalk (arrow). The abnormalities are non-discrete and radiologically inconsistent with a microadenoma or invasive macro adenoma of the pituitary gland. (b) Dedicated thin-section coronal contrast-enhanced T1-weighted image of the pituitary demonstrates the abnormal enhancement and thickening of the pituitary stalk as well as the cavernous sinus and pituitary parenchyma in more detail. (c) Dedicated thin-section sagittal contrast-enhanced T1-weighted image of the pituitary demonstrates the abnormal generalised thickening and enhancement of the pituitary stalk (arrow) consistent with granulomatous infundibulitis

Severe

localised granulomatosis with polyangiitis (Wegener’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. Axial intracranial contrast-enhanced T1-weighted MR image after six pulses of cyclophosphamide. There is reduction in the volume of abnormal cavernous sinus enhancing chronic inflammatory tissue (arrows) compared with pre-treatment imaging