Myxoinflammatory fibroblastic sarcoma

Myxoinflammatory fibroblastic sarcoma (MIFS) is an uncommon intermediate grade fibroblastic/myofibroblastic tumor.

Epidemiology

It typically affects adults.

Clinical presentation

The patient may present with painless swelling.

Pathology

This tumor is microscopically characterized by solid nests of atypical spindle and epithelioid cells in a myxoid stroma accompanied by dense inflammatory infiltrates.

Location

It most commonly occurs in the distant extremities. The fingers are a particularly common site of occurrence (which is then called acral myxoinflammatory fibroblastic sarcoma)

Radiographic features

MRI

MRI features can have some variation . Usually seen as a poorly circumscribed mass involving an underlying tendon sheath in the distal extremities. Can often have a multinodular appearance.

Treatment and prognosis

It generally carries relatively good prognosis with a long life expectancy although frequent local recurrence can occur .

History and etymology

It was first described in 1998 by Meis-Kindblom and Montgomery et al.