The orbitofrontal arteries, or frontobasal arteries, supply the orbitofrontal cortex. They consist of both medial and lateral orbitofrontal arteries.
The medial orbitofrontal artery (MOFA) is most commonly the first branch of the A2 segment of the anterior cerebral artery. It arises distal to the anterior communicating artery and passes anteriorly and inferiorly towards the anterior cranial fossa and passes around the gyrus rectus. It terminates at the orbitofrontal cortex, supplying the orbital gyri and inferomedial portion of the frontal lobe.
The lateral orbitofrontal artery (LOFA) is variable in its origin, however, is most commonly the first cortical branch of the superior trunk of the middle cerebral artery bifurcation. The LOFA passes between the frontal and temporal lobes from posteroinferior to anterosuperior to arrive at the posterolateral orbitofrontal cortex surface. Here it primarily supplies the lateral orbitofrontal cortex.