Paclitaxel lung toxicity

Paclitaxel lung toxicity is a from of drug induced lung disease that can precipitate following the use of paclitaxel which is a chemotherapeutic agent commonly used in the treatment of breast, ovarian, and non– small cell lung cancers.

Several forms have been described

  • hypersensitivity reactions :
    • thought to occur in around 3-30% of treated patients
    • most frequently manifest as dyspnea, bronchospasm, urticaria, hypotension, and erythematous rashes
  • acute bilateral pneumonitis 
    • thought to occur in less than 1% of patients receiving 3-hour infusions of paclitaxel
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