Prämature Thelarche
Premature thelarche refers to onset of female breast development before age 7–8 years. As with age-appropriate thelarche, premature thelarche may be asymmetric or unilateral.
Premature thelarche may occur as an isolated event or as part of precocious puberty. Isolated premature thelarche generally occurs in girls aged 1-3 years and is nonprogressive.
Radiographic features
Ultrasound
At sonography, premature thelarche appears as normal developing breast tissue without a discrete lesion.
General imaging work up
Radiological evaluation for suspected precocious puberty should include a bone age assessment and abdominal and pelvic sonography to look for evidence of maturation of the uterus and ovaries.
Other work up
In addition, the ovaries and adrenal glands should be evaluated for estrogen-producing lesions, including
- functioning ovarian cysts
- juvenile granulosa cell tumors of the ovary
- feminizing adrenal cortical tumors - rare
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