primary lateral sclerosis
Primary lateral sclerosis (PLS) is a form of motor neuron disease (MND).
Clinical presentation
Diagnosis
The diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics.
Pathology
It is characterized by a slowly progressive upper motor neuron syndrome.
Differential diagnosis
- upper motor neuron-predominant forms of amyotrophic lateral sclerosis: remains a significant challenge in the early symptomatic phase
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