Radiation recall pneumonitis
Radiation
recall pneumonitis triggered by an immune checkpoint inhibitor following re-irradiation in a lung cancer patient: a case report. CT lung window (A, B) and contrast window (C, D) before pembrolizumab plus nab-paclitaxel, captured on November 5th, 2020; E, F CT lung and contrast window on May 1st, 2021; G The mucosa of right middle bronchus: is normal and the bronchus is clear. H The mucosa of the left upper lobe is post-surgery appearance and the bronchus is clear. I, J CT lung and contrast window captured on June 5th, 2021 (one month after steroids). Significant abnormal findings noted (arrow)
Radiation recall pneumonitis (RRP) is a rare reaction occurring in previously irradiated areas of pulmonary tissue after the application of triggering agents (e.g. chemotherapeutic agents or immunomodulators etc). It is not thought to be due to the direct effect of radiation. Classically this has been described with taxanes, anthracyclines, gemcitabine, erlotinib and nivolumab .
See also
