ROS1 mutation
The ROS1 mutation is a mutation occurring in the ROS1 oncogene on chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.
It is thought to be present in several cancers of the subtype non-small cell lung cancers (NSCLC) (1-2%).
Clinical importance
Useful for assessing appropriateness of treatment agents such as crizotinib.
History and etymology
It is thought to have been first identified by Rikova et al .
See also
