subcortical heterotopia
Subcortical heterotopia is a form of nodular grey matter heterotopia. They can be divided into:
- nodular form: extend from the ventricle into the white matter
- curvilinear form: extend from the cortex into the underlying white matter
- mixed form
Terminology
The term laminar heterotopia is sometimes used ambiguously to refer to some of these patients . It is important to note that these patients should not be confused with lissencephaly type I-subcortical band heterotopia spectrum which is distinct on both imaging and at an underlying genetic level.
Clinical presentation
Epilepsy is very common and typically presents in childhood . It is usually associated with variable developmental delay .
Radiographic features
Subcortical heterotopias are continuous with the overlying cortex or underlying ventricle and are associated with severe abnormalities of the involved hemisphere, characterized by :
- diffuse reduction in size of the hemisphere
- distorted ventricles
- diminished and abnormal white matter
- thinned overlying cortex with shallow sulci
- distorted basal ganglia
These features are helpful in distinguishing this entity from subependymal grey matter heterotopia and lissencephaly type I-subcortical band heterotopia spectrum.
Siehe auch:
Assoziationen und Differentialdiagnosen zu subcortical heterotopia:
