Thrombolysis in cerebral infarction (TICI) scale

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The thrombolysis in cerebral infarction (TICI) grading system was described in 2003 by Higashida et al.  as a tool for determining the response of thrombolytic therapy for ischemic stroke. In neurointerventional radiology it is commonly used for patients post endovascular revascularization. Like most therapy response grading systems, it predicts prognosis.

Classification

The original description was based on the angiographic appearances of the treated occluded vessel and the distal branches:

  • Grade 0: no perfusion
  • Grade 1: penetration with minimal perfusion
  • Grade 2: partial perfusion
    • Grade 2A: only partial filling (less than two-thirds) of the entire vascular territory is visualized
    • Grade 2B: complete filling of all of the expected vascular territory is visualized but the filling is slower than normal
  • Grade 3: complete perfusion

In 2013 Fugate et al. reported marked variability in its definitions and application .

A consensus paper from three collaborative groups published in Stroke in 2013  recommended a modified scale, and a change of name from Thrombolysis in Cerebral Infarction to modified Treatment in Cerebral Infarction (mTICI), to better reflect the increased use of endovascular therapies.