Uromodulin
Newborn with
prenatal hydronephrosis. Sagittal US of the kidneys shows multiple echogenic lesions in the renal pyramids bilaterally which resolved on a repeat ultrasound performed one month later.The diagnosis was Tamm Horsfall proteins.
Tamm-Horsfall proteins, also known as uromodulin, may be a cause of echogenic renal pyramids in a neonate.
Tamm-Horsfall proteins are physiologically excreted by the renal tubular epithelium. They are most often encountered on neonatal renal ultrasound, where the concentrated proteins in the renal pyramids may mimic nonobstructing renal stones . It is considered a normal finding .
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