Werner syndrome is a progeroid rare autosomal recessive condition attributed to chromosome 8. It should not to be confused with similarly sounding Wermer syndrome.
Werner syndrome is characterized by
- premature senescence
- short stature
- scleroderma-like skin changes such as hyperkeratotic skin, soft tissue calcification
- endocrine abnormalities such diabetes mellitus and hypogonadism
The syndrome also carries an increased risk of malignancy (particularly sarcoma formation ).
A general manifestation is valvular, soft tissue and/or arterial calcification from premature atherosclerosis. Musculoskeletal manifestations includes:
- osteoporosis: either generalized or localized to the peripheries
- osteosclerosis: phalangeal predominant
First described by Otto Werner, German scientist, in 1904.
- Systemische Sklerodermie
- multiple endokrine Neoplasie Typ 1
- Hutchinson-Gilford-Progerie-Syndrom (HGPS)