Longitudinally extensive spinal cord lesion
Neuromyelitis
optica spectrum disorder • Neuromyelitis optica - Ganzer Fall bei Radiopaedia
Neurosarcoidosis
• Sarcoidosis of the spinal cord - Ganzer Fall bei Radiopaedia
Neuromyelitis
optica spectrum disorder • Neuromyelitis optica (NMO) - Ganzer Fall bei Radiopaedia
Longitudinally
extensive spinal cord lesion • Systemic lupus erythematosus myelitis - Ganzer Fall bei Radiopaedia
Transverse
myelitis • Transverse myelitis evolution in MRI - Ganzer Fall bei Radiopaedia
Longitudinally extensive spinal cord lesions (LESCL), also known as longitudinally extensive transverse myelitis (LETM), represent extensive involvement of the spinal cord, with abnormal T2 signal traversing at least three vertebral body segments in length.
Differential diagnosis
They are typical of neuromyelitis optica (NMO) but can be seen in a number of other conditions, including :
- neuromyelitis optica (NMO)
- opticospinal form of Asian MS (OSMS)
- multiple sclerosis
- confluent short segment lesions mimicking LESCL
- anti-MOG associated encephalomyelitis
- autoimmune GFAP astrocytopathy
- systemic illness
- neurosarcoidosis
- Sjögren syndrome
- systemic lupus erythematosus (SLE)
- Behçet disease
- paraneoplastic myelitis
- other causes of transverse myelitis
- idiopathic (aquaporin-4 negative)
- post-infectious
- vascular
