Synucleinopathie

Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits and can further be divided into those with and those without the formation of Lewy bodies :

Pathology

α-synuclein is a neuronal protein of unclear function which accounts for approximately 1% of brain weight .

In addition to cerebral accumulation, α-synuclein also accumulates in the gastrointestinal tract resulting in symptoms .

Editor: more detail is required here pertaining to the genetic and biochemical underpinnings of these diseases, as well as any commonalities in presentation/demographics/ radiographic appearances.

Siehe auch: