HER-2 mutations in lung cancer
Human epidermal growth factor receptor 2 (HER-2) mutations may be detected in approximately 3% of lung adenocarcinomas .
Radiographic features
CT
Early studies have suggested HER2-mutant tumors exhibit more aggressive features in general and tend to:
- exhibit a locally-invasive behavior compared with KRAS-mutant tumors
- show preponderance for pleural retractions compared with KRAS- and EGFR-mutant tumors
- present with greater nodal metastatic spread compared KRAS-mutant tumors
See also
- HER-2/NEU: general article
- KRAS mutation
- EGFR mutation