Synucleinopathie
Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits and can further be divided into those with and those without the formation of Lewy bodies :
- synucleinopathies with Lewy bodies
- Parkinson disease
- Dementia with Lewy bodies (aka Lewy body disease)
- synucleinopathies without Lewy bodies
- multiple systemic atrophy (MSA)
- pure autonomic failure
- rapid eye movement (REM) sleep behavior disorder
Pathology
α-synuclein is a neuronal protein of unclear function which accounts for approximately 1% of brain weight .
In addition to cerebral accumulation, α-synuclein also accumulates in the gastrointestinal tract resulting in symptoms .
Editor: more detail is required here pertaining to the genetic and biochemical underpinnings of these diseases, as well as any commonalities in presentation/demographics/ radiographic appearances.
Siehe auch:
Assoziationen und Differentialdiagnosen zu Synucleinopathie:
