4D syndrome

4D syndrome is a term used to describe a manifestation of syndromic glucagonomas, a type of pancreatic endocrine tumor.

  • D: dermatitis
    • necrolytic migratory erythema - a widespread rash, tending to involve perioral and perigenital regions
    • oral rashes (angular stomatitis, cheilitis)
    • tend to resolve upon removal of the tumor
  • D: mild diabetes mellitus
  • D: deep vein thrombosis
  • D: depression - may be related to severe chronic dermatosis