alveolar rhabdomyosarcoma
Alveolar rhabdomyosarcomas are a type of rhabdomyosarcoma and account for 20-40% of all rhabdomyosarcomas .
Epidemiology
Unlike embryonal rhabdomyosarcomas, which are more common, these tumors occur in slightly older individuals, typically 10-25 years of age .
Pathology
Location
Although these tumors can be found essentially anywhere, they are more frequently situated in the deep compartments of the extremities .
Genetics
Specific genetic abnormalities have been identified, that are specific for alveolar rhabdomyosarcomas. They include t(2;13) and t(1;13) chromosomal translocations resulting in PAX3-FKHR and PAX7-FKHR gene fusions .
Compared to the other two types (embryonal and pleomorphic rhabdomyosarcomas) it has the worst prognosis .
Radiographic features
The features are non-specific (see radiographic features in the parent article: rhabdomyosarcoma), although in general alveolar rhabdomyosarcomas tend to have multiple areas of necrosis .
Siehe auch:
und weiter:
Assoziationen und Differentialdiagnosen zu alveolar rhabdomyosarcoma:
