Brownell-Oppenheimer variant of sporadic Creutzfeldt-Jakob disease

The Brownell-Oppenheimer phenotypic variant of sporadic Creutzfeldt-Jakob disease (CJD) is a distinct clinical entity with predominant gait ataxia, linked to molecular subtype VV2 . The EEG findings in patients with Oppenheimer-Brownell phenotype usually reveal the absence of periodic sharp-wave complexes (PSWCs) . The protein 14-3-3 is usually elevated in CSF analysis in patients with VV2 variant of sCJD . MRI shows cerebellar atrophy and selective signal abnormalities in the cerebellar cortex .