diffuse cerebellar atrophy
Diffuse atrophy of the cerebellum refers to a progressive and irreversible reduction in cerebellar volume. It is a relatively common finding and found in a wide variety of clinical scenarios.
Diffuse cerebellar atrophy can be difficult to distinguish from global cerebellar hypoplasia on a single study and can only be distinguished from the latter by demonstrating or implying (clinically) that there has been progressive change over time .
Diffuse atrophy can result from a variety of causes:
- normal aging
- multiple system atrophy
- hereditary cerebellar ataxias
- chronic temporal lobe epilepsy (independently from phenytoin use)
- paraneoplastic cerebellar degeneration
- superficial siderosis
- Fahr disease: atrophy not specific to cerebellum
- cerebrotendinous xanthomatosis
- JC virus granule cell neuronopathy