clear cell carcinoma of the cervix

Clear cell carcinoma of the cervix (CCCC) is a rare adenocarcinoma subtype of cervical cancer.


Due to association with diethylstilbestrol (DES) exposure in some patients, this subtype may have a younger age at presentation than other histological subtypes. This subtype can sometimes present in the pediatric age group .


The tumor can have solid, tubulocystic or papillary patterns .

  • in utero DES exposure in some patients ( ~6%) 
  • no association with HPV DNA (unlike other cervical cancer subtypes)

Treatment and prognosis

In selected cases (particularly pediatric patients), radical trachelectomies have been carried out with fertility sparing .

See also

Siehe auch:
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