Granularzelltumor der Mamma

Mimickers of

breast malignancy: imaging findings, pathologic concordance and clinical management. Granular cell tumor. A 65-year-old woman presented for further evaluation of a focal asymmetry detected on screening mammopgrahy. Craniocaudal and lateral spot compression views (a, b) show a small irregular mass with spiculated margins (arrows). Color Doppler (c) and grayscale (d) ultrasound shows a corresponding irregular mass with internal vascularity (arrows). Core needle biopsy yielded granular cell tumor which was treated with surgical excision

insightsimaging.springeropen.com • CC-by-4.0

Granular cell

tumor of the breast • Granular cell tumor of the breast - Ganzer Fall bei Radiopaedia

Holland, M. Granular cell tumor of the breast. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-19062 • CC by-nc-sa 3.0 (modified)

Granular cell

tumor of the breast • Granular cell tumor of the breast - Ganzer Fall bei Radiopaedia

Alsmair, A. Granular cell tumor of the breast. Case study, Radiopaedia.org. (accessed on 08 Nov 2022) https://doi.org/10.53347/rID-95939 • CC by-nc-sa 3.0 (modified)

Granular cell

tumor of the breast: a case report. Ultrasound demonstrated a 17mm hypoechoic, heterogeneous, irregular and poorly limited mass, suspicious for malignancy.

jmedicalcasereports.biomedcentral.com • CC-by-4.0

Granular cell

tumors: a report of six cases. (a) Case 1. Ultrasonography revealed a tumor 8 × 9 mm in size with irregular borders and rupture of the anterior border of the mammary gland. Mammography revealed a tumor with irregular borders and spicule. (b) Case 2. Ultrasonography revealed a tumor 7 × 8 mm in size with irregular borders and rupture of the anterior border of the mammary gland.

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Radiopaedia • CC-by-nc-sa 3.0 • de

A granular cell tumor (GrCT) of the breast is an uncommon, usually benign tumor which is possibly of neural origin.

Epidemiology

They tend to occur at a younger age than other types of breast cancer . The age range of presentation, however, can be very variable although they occur more commonly in pre-menopausal women.

Clinical presentation

Clinically they can mimic carcinoma because of their fibrous consistency and their hardness, thus presenting as a palpable mass.

Pathology

GrCTs can occur in a variety of visceral and cutaneous sites. Most authors favor a Schwann cell origin, based on histochemical, immunohistochemical, and ultrastructural findings and on occurrence of typical lesions, within nerves.

The breast accounts of ~5-8% of all granular cell tumors . Cells with eosinophilic granules with abundant cytoplasm are characteristic. Positive immunohistochemical staining of the cells for S-100 protein, CD68 (KP-1) NSE, and CEA is indicative of this tumor . There is a negative reaction against cytokeratin.

Location

GCTs tend to occur most commonly in the upper inner quadrant corresponding to the cutaneous sensory territory of the supraclavicular nerve.

Radiographic features

Imaging features on both ultrasound and mammography can mimic that of more sinister breast malignancy.

Mammography

On mammography, these tumors can present as an ill-defined or spiculated lesions, similar to primary carcinoma.

Breast ultrasound

On ultrasound, this tumor can appear as a solid, hypoechoic, ill-defined mass, associated with a posterior shadowing, or as a well-circumscribed oval mass, associated with a posterior enhancement, depending on the extent of infiltration and degree of reactive fibrosis.

History and etymology

Granular cell tumors, in general, were first described by A I Abrikosoff in 1926 as a “myoblastic myoma” .

Treatment and prognosis

Usually, a wide local surgical excision is performed. While less than 1% of tumors are malignant, local recurrences have been reported with incomplete excision.