Lebermetastasen malignes Melanom

Metastatic

uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone. MRI abdomen T2-hyperintense signal. a & b showing multiple metastatic lesions to the liver before the initiation of immunotherapy. c showing progression of the disease after 4 cycles of nivolumab. The largest lesion was 5.5 cm in the right hepatic lobe. d showing a mixed response after 4 cycles on ipilimumab/nivolumab

Chemosaturation

with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience. a: Patient case. Of note, a depicts a patient with liver dominant metastatic uveal melanoma at baseline before first chemosaturation with percutaneous hepatic perfusion (CS-PHP) treatment. The patient responded with partial remission 3 month after first CS-PHP procedure (b). Sustained hepatic tumor control was achieved for 30 months by five treatments with CS-PHP, while extrahepatic progressive disease was noted (c). After a sixth CS-PHP application and 35 months after first CS-PHP therapy, progression was diagnosed intra- and extrahepatically (d). b: Patient case. Of note, (a) T2 weighted images of a patient with liver dominant metastatic uveal melanoma at baseline before first chemosaturation with percutaneous hepatic perfusion (CS-PHP) treatment. The patient responded with partial remission 3 month after first CS-PHP procedure (b). Sustained hepatic tumor control was achieved for 13 months (c). Progression was diagnosed intrahepatically after 17 months, and patient was scheduled for a new CS-PHP (d)

Ruptured

hepatic metastases of cutaneous melanoma during treatment with vemurafenib: an autopsy case report. Sequential images of abdominal computed tomography (CT). These images are from September 2012 (a), November 2012 (b), and December 2012 (c). There is a metastatic tumor in the right lobe of the liver (a). Initially, the hepatic metastases considerably respond to vemurafenib treatment, and they become almost invisible (b). Later, they grow rapidly and rupture, resulting in a large amount of free fluid within the peritoneal cavity surrounding the liver (c). The yellow arrow demonstrates the same tumor in each image