Liquefactive necrosis

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Liquefactive necrosis is a form of necrosis where there is transformation of the tissue into a liquid viscous mass.

Pathology

In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes leading to a soft, circumscribed lesion which can consist of fluid with remains of necrotic tissue or pus.

Associations

It is commonly associated with infection, dependent on the site of involvement.

Location

Reported organs include:

  • lung
    • a lung abscess if considered a form of liquefactive necrosis
  • brain
  • spleen
  • pancreas