Nodular filling defects of duodenum (differential)

Nodular filling defects due to mucosal lesions in the duodenum are due to a number of processes. For a differential list which includes non-mucosal lesions see duodenal filling defects.

The differential diagnosis for mucosal lesions includes:

• heterotopic gastric mucosa
  • 1-2 mm
  • clustered
  • only slightly elevated
• benign lymphoid hyperplasia
  • 1-2 mm
  • discrete nodules
  • diffusely scattered through the duodenal bulb
  • seen in patients with decreased immunity
• Brunner gland hyperplasia
  • >1 cm
  • diffusely scattered through the duodenal bulb
  • cobblestone appearance
  • smooth
• Peutz-Jeghers syndrome
• Cronkhite-Canada syndrome
• familial adenomatous polyposis (FAP)