Ovarian Sertoli-Leydig cell tumor

Ovarian Sertoli-Leydig cell tumors (SLCT), also known as ovarian androblastomas, are a subtype of ovarian sex cord-stromal tumor.


They are rare and only account for ~0.5% of all ovarian tumors. While they can present at any age, they typically present <30 years old, with a mean age of 14 years.

Clinical presentation

In ~30-50% of patients, the presenting symptoms are related to clinical signs of androgenic activity . Many patients have symptoms of virilization depending on the quantity of androgen production. A small subset is hyperoestrogenic.

Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain. The majority of patients present with stage I disease.


Most tumors are unilateral (>90% of cases) and confined to the ovaries. These tumors are characterized by the presence of testicular structures that produce androgens. However, only 30% are hormonally active.

Ovarian SLCTs can be divided into four subtypes:

  • well-differentiated
  • intermediately-differentiated
  • poorly-differentiated
  • retiform

The tumors may contain heterologous elements in approximately 20% of cases. These can, in turn, be further separated into two basic types: endodermal and mesenchymal. Heterologous hepatic differentiation is responsible for elevated AFP levels .

  • pure Sertoli cell tumor of ovary :

Radiographic features

SLCTs are usually unilateral.


Imaging features are nonspecific and variable. SLCT may manifest as a well-defined, enhancing solid mass or as a cystic lesion . It typically presents as a solid mass with intratumoral cysts.


The signal intensity on T2-weighted MR images depends on their fibrous content. Most tumors demonstrate predominantly low T2 signal intensity with scattered areas of high signal intensity.

Treatment and prognosis

Most tumors are benign although ~10-20% can be malignant.

See also

Siehe auch: