Perugini grading scale

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The Perugini grading scale is a semi-quantitative method of scoring cardiac uptake following injection of 99mTc-DPD, 99mTc-Pyrophosphate or 99mTc-HMDP scintigraphy in the investigation of cardiac amyloidosis.

Classification

  • grade 0: no cardiac uptake and normal bone uptake
  • grade 1: cardiac uptake which is less than bone uptake
  • grade 2: cardiac uptake with intensity similar to or greater than bone uptake
  • grade 3: cardiac uptake with much reduced or absent bone signal