pulmonary tumourlet
Pulmonary tumourlets refer to a type of neuroendocrine cell proliferation in the lung. They are at the benign end of the spectrum of neuroendocrine cell proliferation when diffuse idiopathic pulmonary neuroendocrine cell hyperplasia DIPNECH breach basement membrane but remain less than 5 mm in diameter.
Epidemiology
There is a recognized female predilection. Tumourlets are generally encountered in patients around 60 to 70 years of age .
Clinical presentation
Most patients tend to be asymptomatic at diagnosis.
Pathology
They are thought to represent tiny peripheral pulmonary carcinoids that differ mainly in size from the larger lesions identified as carcinoid tumors with which they share histological, ultrastructural, and immunohistochemical features. Due to this, they are also called pulmonary carcinoid tumourlets by some authors . Tumourlets are usually defined as lesions <5 mm in diameter. They are often multiple.
Tumourlets also lack mitotic activity and do not show necrosis .
Associations
They often occur in association with airway damage, emphysema and fibrosis
Radiographic features
CT
Pulmonary tumourlets may be seen as small pulmonary nodules and mosaic attenuation secondary to air trapping on CT.
Siehe auch:
- Lungenrundherd
- neuroendocrine tumours of the lung
- diffuse idiopathische pulmonale neuroendocrine Zellhyperplasie
- peripheral pulmonary carcinoids
und weiter:
Assoziationen und Differentialdiagnosen zu pulmonary tumourlets:
